Dosing Recommendations and Renal Dose Adjustments
Recommended dosage
ZAYNICH™
3 grams
2 grams cefepime and 1 gram zidebactam
- One-hour IV infusions
- Taken every 8 hours
- 7–10 day course of therapy
- Adult patients without renal impairment (eGFR ≥60 mL/min)
Dosage adjustment in renal impairment
Dosage adjustment is recommended in adult patients with renal impairment who have an eGFR less than 60 mL/min. Administer each intravenous infusion over 1 hour for patients with renal impairment. The duration of treatment is 7 to 10 days.
| eGFRa (mL/min) | Doseb | Dosing interval |
|---|---|---|
| 60 to 89 | ZAYNICH 3 gramsc | Every 8 hours |
| 30 to 59 | ZAYNICH 1.5 gramsd | Every 8 hours |
| 15 to 29 | ZAYNICH 1.5 gramsd | Every 12 hours |
| 8 to 14, with or without intermittent hemodialysis (IHD)e | ZAYNICH 1.5 gramsd | Every 24 hours |
- aAs calculated using the 4-variable Modification of Diet in Renal Disease (MDRD) formula.
- bThe total duration of treatment is for 7 to 10 days.
- cProvides 2 grams cefepime and 1 gram zidebactam.
- dProvides 1 gram cefepime and 0.5 grams zidebactam.
- eOn hemodialysis days, recommended dose should be administered after a hemodialysis session. On days when hemodialysis is not performed, administer recommended dose 24 hours after the previous dose.
See full Prescribing Information for preparation, reconstitution, and administration instructions (section 2.3) and drug compatibilities (section 2.4).
Reference: 1. ZAYNICH (cefepime and zidebactam) US Prescribing Information. Wockhardt Bio AG; 2026.